8-Chloro-3-bromoimidazo[1,2-a]pyrazine

8-Chloro-3-bromoimidazo[1,2-a]pyrazine - Names and Identifiers

Name	3-bromo-8-chloroimidazo[1,2-a]pyrazine
Synonyms	8-Chloro-3-bromoimidazo[1,2-a]pyrazine 3-Bromo-8-chloroimidazo[1,2-a]pyrazine 3-bromo-8-chloroimidazo[1,2-a]pyrazine 3-BROMO-8-CHLOROIMIDAZO[1,2-A]PYRAZINE imidazo[1,2-a]pyrazine, 3-bromo-8-chloro- Imidazo[1,2-a]pyrazine, 3-bromo-8-chloro-
CAS	143591-61-1
InChI	InChI=1/C6H3BrClN3/c7-4-3-10-6-5(8)9-1-2-11(4)6/h1-3H

8-Chloro-3-bromoimidazo[1,2-a]pyrazine - Physico-chemical Properties

Molecular Formula	C6H3BrClN3
Molar Mass	232.47
Density	2.03±0.1 g/cm3(Predicted)
pKa	-1.45±0.30(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	1.768

8-Chloro-3-bromoimidazo[1,2-a]pyrazine - Introduction

3-bromo-8-chloroimidazo[1,2-a]pyrazine is an imidazo[1,2-a]pyrazine compound containing bromine and chlorine atoms. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 3-bromo-8-chrooimidazo [1,2-a]pyrazine is a white crystalline solid.
-Solubility: Soluble in some organic solvents, such as chloroform, dimethyl sulfoxide, etc.
-Melting point: About 250-255 degrees Celsius.

Use:
-3-bromo-8-chrooimidazo [1,2-a]pyrazine is commonly used as an intermediate and reagent in organic synthesis.
-The compound has certain biological activity in the field of medicine, and can be used to synthesize anti-tumor, anti-virus, antibacterial and other drugs.

Method:
-3-bromo-8-chrooimidazo [1,2-a]pyrazine can be prepared by various methods. The common methods are as follows:
1. Reacting 4,5-dichloroimidazole with 2-bromoketone to obtain 3-bromo-4, 5-dichloroimidazole;
2.3-bromo-8-chloro imidazole [1,2-a]pyrazine was prepared by catalytic chlorination of 3-bromo -4,5-dichloro imidazole with acetone copper chloride.

Safety Information:
- 3-bromo-8-chloroimidazo[1,2-a]pyrazine has low safety and is an organic halogenated compound with certain toxicity and potential danger.
-Use should follow the laboratory's safe practices and be equipped with appropriate personal protective equipment, such as gloves, goggles, protective clothing, etc.
-Avoid direct contact of the compound with skin, eyes and respiratory tract.
-in the storage and handling process should pay attention to prevent its reaction with flammable substances, oxidants, etc.

Last Update：2024-04-09 02:00:42